This web page was produced as an assignment for Genetics 677, an undergraduate course at UW‐Madison.
BLM Gene Ontology
Using AmiGO website, protein associations for the BLM gene in Homo sapiens are found and shown as follows:
Click at this file to view the tree of BLM Gene Ontology Interactions in Homo sapiens
ontology_tree.png | |
File Size: | 3798 kb |
File Type: | png |
Gene Ontology Annotation Database
Using GOA, I was able to obtain descriptions of BLM's biological processes, molecular functions, and cellular components that were similarly to those stated by AmiGo. Click here to see the full descriptions by GOA. However, BLM was described by GOA as being localized to intracellular and nucleus while AmiGo found BLM to localize to more places (see above). In conclusion, the descriptions by GOA is more general than those by AmiGO.
Analysis
I prefered to use AmiGO to look for gene ontology because it gives more information about a gene. Also, it provides a tree/diagram of gene ontology to help users to better understand the functions of a certain gene.
Based on the results from AmiGO and GOA, I knew that the BLM protein is mainly localized to nucleus and has an important role in DNA metabolism such as DNA repair, DNA replication, recombination and telomere maintenance.
Based on the results from AmiGO and GOA, I knew that the BLM protein is mainly localized to nucleus and has an important role in DNA metabolism such as DNA repair, DNA replication, recombination and telomere maintenance.